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Imprint De utsch En glish. Involved Groups Systems Immunology. Additionally, researchers will meet and exchange knowledge in regularly. Print Send per email Share. Both cells form a ring-shaped structure made of different proteins at the point of contact between the cells — termed immunological synapse — over which they can exchange information. In these models, they simulated different conditions and influencing factors and were able to demonstrate that the different molecules exert an influence on each other in terms of their arrangement although they do not interact directly. Cell Reports,DOI:

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    These tasks are shared among different cell types: The T-cell makes contact with the antigen-presenting cell by means of specialized adhesion molecules which initially are randomly distributed over the cell surface. We only use this information for improving our services.

    A T-cell is made fit for the fight against pathogens by a dendritic cell.

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    Researchers of the Helmholtz Centre for Infection Research HZI and the Braunschweig Integrated Centre of Systems Biology BRICSin collaboration with researchers at the University of Oxford UKhave now simulated the dynamic arrangement of these components using computer models and have subsequently been able to make inferences on the mechanisms involved in the formation of synapses.

    Microscope image shows an immunological synapse. If an immune cell recognises foreign matter, it can present it to another immune cell. A T-cell is made fit for the fight against pathogens by a dendritic cell.

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    Press Release – Helmholtz Zentrum München

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    These tasks are shared among different cell types: The large adhesion molecules accumulate around them in an outer ring. In these models, they simulated different conditions and influencing factors and were able to demonstrate that the different molecules exert an influence on each other in terms of their arrangement although they do not interact directly.

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    How do we use this knowledge for therapies? This, however, could not be proved for the other molecules. Third party content and cookies e.

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    Anastasios Siokis, Philippe A. At the end of this process the T-cell is either activated or remains inactive.

    Print Send per email Share. Patients with lymphoma metastases have significantly reduced chances of survival. HZI researchers have investigated the formation of immunological synapses over which immune cells exchange information The immune system protects the human body against pathogens thus keeping it healthy.

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